Kaminskaia G O, Puriaeva N L, Stepanian I E
Vrach Delo. 1990 Jan(1):44-6.
The diurnal excretion of oxiprolin with the urine and content of its fractions in the blood serum was determined in 52 patients with different disseminated processes in the lung at the active phase. An increase of the peptide-bound oxiproline and increase of its free fraction was characteristic of all patients. The protein-bound oxiprolin showed major individual changes. Its increase was often noted in patients with roentgenologically visualized fibrosis changes in the lungs, decrease--in fresh granulomatous processes. Corticosteroid therapy for 1-1.5 months produced no effect on the collagen metabolism indices.
对52例处于活动期、肺部有不同播散性病变的患者，测定了其尿中氧脯氨酸的昼夜排泄量及其血清中各组分的含量。所有患者的肽结合型氧脯氨酸均增加，其游离组分也增加。蛋白结合型氧脯氨酸呈现出较大的个体差异。在肺部有X线可见纤维化改变的患者中常可见其增加，而在新鲜肉芽肿性病变患者中则降低。1 - 1.5个月的皮质类固醇治疗对胶原代谢指标无影响。
