Chou H, Ogawa N, Asanuma M, Hirata H, Kondo Y, Mori A
Department of Neuroscience, Okayama University Medical School, Japan.
Brain Res Mol Brain Res. 1993 Aug;19(3):211-4. doi: 10.1016/0169-328x(93)90028-n.
The effects of a single administration of muscarinic cholinergic agents on the level of muscarinic M1-receptor messenger RNA (M1-R mRNA) in the rat striatum were studied. Carbachol increased the M1-R mRNA expression rapidly and transiently, while trihexyphenidyl decreased it. These results suggest that muscarinic cholinergic agents participate in the positive regulation of muscarinic receptor mRNA in the early stage after treatment, contrary to the negative regulation in the chronic stage.
研究了单次给予毒蕈碱胆碱能药物对大鼠纹状体中毒蕈碱M1受体信使核糖核酸（M1-R mRNA）水平的影响。卡巴胆碱迅速且短暂地增加了M1-R mRNA的表达，而苯海索则降低了它。这些结果表明，与慢性期的负调节相反，毒蕈碱胆碱能药物在治疗后的早期参与了毒蕈碱受体mRNA的正调节。
