微血管性心绞痛患者的胰岛素抵抗、葡萄糖耐量异常和高胰岛素血症。

Insulin resistance, glucose intolerance, and hyperinsulinemia in patients with microvascular angina.

作者信息

Fuh M M, Jeng C Y, Young M M, Sheu W H, Chen Y D, Reaven G M

机构信息

Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.

出版信息

Metabolism. 1993 Sep;42(9):1090-2. doi: 10.1016/0026-0495(93)90264-o.

DOI:10.1016/0026-0495(93)90264-o

PMID:8412759

Abstract

Plasma glucose and insulin responses to oral glucose and insulin-mediated glucose disposal were determined in 20 patients with microvascular angina and 20 normal volunteers who were similar in terms of age, gender distribution, and degree of obesity. Plasma glucose and insulin responses to a 75-g oral glucose challenge were significantly higher in those with microvascular angina (P < .001), as were steady-state plasma glucose concentrations after a 180-minute infusion of somatostatin, glucose, and insulin (12.2 +/- 1.0 v 7.6 +/- 0.6 mmol/L, P < .001). Since steady-state plasma insulin concentrations were similar in the two groups (627 +/- 32 v 631 +/- 29 pmol/L), these data indicate that patients with microvascular angina are insulin-resistant, glucose-intolerant, and hyperinsulinemic compared with a matched group of normal volunteers.

摘要

对20例微血管性心绞痛患者和20名年龄、性别分布及肥胖程度相近的正常志愿者，测定了其口服葡萄糖后的血浆葡萄糖及胰岛素反应，以及胰岛素介导的葡萄糖清除情况。微血管性心绞痛患者口服75g葡萄糖后的血浆葡萄糖及胰岛素反应显著更高（P <.001），在输注生长抑素、葡萄糖和胰岛素180分钟后的稳态血浆葡萄糖浓度也是如此（12.2±1.0对7.6±0.6 mmol/L，P <.001）。由于两组的稳态血浆胰岛素浓度相似（627±32对631±29 pmol/L），这些数据表明，与配对的正常志愿者组相比，微血管性心绞痛患者存在胰岛素抵抗、葡萄糖不耐受和高胰岛素血症。