Nordström L, Oistämö S, Olmebring F
Scand J Infect Dis. 1977;9(1):63-4. doi: 10.3109/inf.1977.9.issue-1.15.
The successful treatment of Candida albicans meningoencephalitis with 5-fluorocytosine (5-FC) is reported. After abdominal surgery with many complications, a 60-year-old man developed severe headache, lumbar pain, mental change. The significance of this was not realized for months. The cerebrospinal fluid (CSF) showed pleocytosis, high protein and low glucose concentration. One CSF culture out of 6 revealed growth of Candida albicans. Serologic tests are also indicated candida infection. After a month of treatment with 5-FC, the severe pain decreased and he improved mentally. After 4 months, the CSF was normal and the 5-FC treatment ended. For the past year, the patient has not shown any signs of relapse.
据报道，5-氟胞嘧啶（5-FC）成功治疗了白色念珠菌性脑膜脑炎。一名60岁男性在腹部手术后出现许多并发症，随后出现严重头痛、腰痛和精神改变。这种情况持续了数月才被重视。脑脊液（CSF）显示细胞增多、蛋白含量高和葡萄糖浓度低。6次脑脊液培养中有1次显示白色念珠菌生长。血清学检测也表明有念珠菌感染。经过1个月的5-FC治疗，剧痛减轻，精神状态有所改善。4个月后，脑脊液恢复正常，5-FC治疗结束。在过去的一年里，该患者未出现任何复发迹象。
