Lee S, Kim H J
Dermatologica. 1981;162(1):36-41. doi: 10.1159/000250231.
A 19-year-old male had chronic mucocutaneous candidiasis with typical granuloma on the face, scalp and genital area. He had defects in cell-mediated immunity (cutaneous anergy to common antigens, but normal number of T lymphocytes and normal lymphocyte transformation with phytohemagglutinin), and there were no endocrine deficiencies. He had systemic involvement, including lungs, kidneys, liver and spleen diagnosed by radiologic studies. In the histologic findings of the skin, typical features were seen of candida granuloma lesions, and hyphae and spores of Candida albicans also were identified in the Malpighian layer. Therapy with 5-fluorocytosine resulted in a remarkable improvement.
一名19岁男性患有慢性黏膜皮肤念珠菌病，面部、头皮和生殖器区域有典型肉芽肿。他存在细胞介导免疫缺陷（对常见抗原皮肤无反应，但T淋巴细胞数量正常，对植物血凝素的淋巴细胞转化正常），且无内分泌缺陷。经放射学检查诊断，他有全身受累，包括肺部、肾脏、肝脏和脾脏。在皮肤组织学检查结果中，可见念珠菌肉芽肿病变的典型特征，在马尔皮基层也鉴定出白色念珠菌的菌丝和孢子。用5-氟胞嘧啶治疗后有显著改善。
