Neri I, Granella F, Nappi R, Manzoni G C, Facchinetti F, Genazzani A R
Department of Gynaecology and Obstetrics, University Centre for Adaptive Disorders and Headache, Italy.
Maturitas. 1993 Jul;17(1):31-7. doi: 10.1016/0378-5122(93)90121-w.
The prevalence and characteristics of primary headaches in a large sample of postmenopausal women were investigated. Seventy-six out of 556 women (13.7%) were affected by headache of either the migraine or tension type. In 82% of cases onset had preceded the menopause. The postmenopausal course of headaches with a premenopausal onset differed according to type of headache and type of menopause. Indeed, while migraine improved in almost two-thirds of cases, tension-type headache worsened or did not change in 70% of cases. However, in women who had undergone surgical ovariectomy, the natural course of migraine was worse than in those who had a physiological menopause (P = 0.003). Among the symptoms covered by the Kuppermann Index, only anxiety and insomnia were correlated with headache. The favourable course of migraine in the postmenopausal period can be attributed primarily to the absence of variations in sex hormone levels although psychological factors also seem to play a fundamental role.
对大量绝经后女性样本中原发性头痛的患病率和特征进行了调查。556名女性中有76名（13.7%）患有偏头痛或紧张型头痛。在82%的病例中，头痛发作先于绝经。绝经前发作的头痛在绝经后的病程因头痛类型和绝经类型而异。实际上，虽然近三分之二的偏头痛病例有所改善，但70%的紧张型头痛病例病情恶化或没有变化。然而，接受手术卵巢切除术的女性中，偏头痛的自然病程比生理性绝经的女性更差（P = 0.003）。在库珀曼指数涵盖的症状中，只有焦虑和失眠与头痛相关。绝经后期偏头痛的良好病程主要可归因于性激素水平没有变化，尽管心理因素似乎也起着重要作用。
