Sexton P T, Jamrozik K, Walsh J
Department of Medicine, University of Tasmania, Hobart.
Med J Aust. 1993 Oct 4;159(7):467-70. doi: 10.5694/j.1326-5377.1993.tb137969.x.
To examine sudden unexpected cardiac death (SUCD) in Tasmanian men and to assess the contribution of these deaths to differences in rates of mortality from ischaemic heart disease (IHD) between regions within Tasmania.
Descriptive epidemiological study based in the community.
Male residents of Tasmania aged 30 to 69 years who died from IHD suddenly and unexpectedly between 1987 and 1989.
Rates and proportions of sudden cardiac death in men who had no prior overt signs of IHD, validated by necropsy and information from the attending doctors.
SUCD accounted for approximately 24% of deaths from IHD among men aged 30 to 69 years in Tasmania. The ratios of observed to expected numbers of deaths occurring among manual and nonmanual workers were similar whereas there was an excess of events among men aged less than 65 years who were not working. Examination of data from necropsy reports revealed that 32% of cases showed evidence of previous "silent" myocardial infarction and 63% showed severe coronary artery disease in two or more vessels, with a further 28% having severe single vessel disease. The contribution of SUCD to total mortality from IHD varied from 20% in the north-west region to 25% in the south and 26% in the north, but the limited number of events makes it uncertain whether the variation in the rate of SUCD is significantly different from that for total mortality from IHD.
The proportion of deaths from IHD among men in Tasmania which are sudden and unexpected and the associated necropsy findings are consistent with those described in other population based studies of sudden cardiac death. Non-participation in the workforce was a risk factor in SUCD. As yet, we cannot distinguish whether the higher mortality rates from IHD among men in northern regions of Tasmania (P < 0.01) were due to differences in SUCD or whether the same rate of SUCD obtains in all regions of the State and the differences in mortality from IHD reflect variation in non-sudden deaths and deaths in people with overt IHD.
研究塔斯马尼亚男性的心脏性猝死(SUCD),并评估这些死亡对塔斯马尼亚不同地区缺血性心脏病(IHD)死亡率差异的影响。
基于社区的描述性流行病学研究。
1987年至1989年间突然意外死于IHD的30至69岁塔斯马尼亚男性居民。
经尸检和主治医生信息验证的、无IHD先前明显体征的男性心脏性猝死发生率和比例。
在塔斯马尼亚30至69岁男性中,SUCD约占IHD死亡人数的24%。体力劳动者和非体力劳动者中观察到的死亡人数与预期死亡人数之比相似,而在未工作的65岁以下男性中,事件发生率过高。对尸检报告数据的检查显示,32%的病例有既往“无症状”心肌梗死的证据,63%的病例显示两支或更多支血管有严重冠状动脉疾病,另有28%有严重单支血管疾病。SUCD对IHD总死亡率的贡献从西北地区的20%到南部的25%和北部的26%不等,但事件数量有限,因此不确定SUCD发生率的差异与IHD总死亡率的差异是否有显著不同。
塔斯马尼亚男性中IHD猝死的比例以及相关尸检结果与其他基于人群的心脏性猝死研究中描述的一致。不参加劳动力是SUCD的一个危险因素。目前,我们无法区分塔斯马尼亚北部男性IHD死亡率较高(P<0.01)是由于SUCD的差异,还是该州所有地区的SUCD发生率相同,而IHD死亡率的差异反映了非猝死和明显IHD患者死亡的差异。