Petrie B F
Department of Psychology, Red Deer College, Alberta, Canada.
Neurotoxicol Teratol. 1993 Jul-Aug;15(4):275-7. doi: 10.1016/0892-0362(93)90009-d.
Two strains of preweanling rats (88 Long-Evans; 120 Sprague-Dawley) were given daily SC injections of either 50 mg/kg naltrexone or the equivalent volume of saline, from birth to postnatal day 21. Brain and body weights were assessed at the end of the injections, and in Long-Evans animals, significant differences were noted on both measures with the outcome favoring the control animals. No significant differences were observed between the naltrexone and control Sprague-Dawley rats. These results disconfirm the hypothesis that increased postnatal growth is accomplished by prolonged early postnatal opioid receptor blockade.
两组断奶前大鼠（88只Long-Evans大鼠；120只Sprague-Dawley大鼠）从出生到出生后第21天，每天皮下注射50毫克/千克纳曲酮或等量生理盐水。在注射结束时评估脑重和体重，在Long-Evans大鼠中，两项指标均存在显著差异，结果有利于对照动物。纳曲酮组和对照Sprague-Dawley大鼠之间未观察到显著差异。这些结果否定了产后生长增加是通过延长出生后早期阿片受体阻断来实现的这一假设。
