造血干细胞的表面分子：脾集落形成中对唾液酸的需求。
Surface molecules of hematopoietic stem cells: requirement for sialic acid in spleen colony formation.
作者信息
Tonelli Q, Meintz R H
出版信息
Science. 1977 Mar 4;195(4281):897-8. doi: 10.1126/science.841316.
PMID:841316
Abstract
Enzymatic treatment was used to test the function of some surface peptides and carbohydrates in hematopoietic spleen colony formation. Proteases and most glycosidases had no effect on spleen colony formation, whereas treatment with Vibrio cholerae neuraminidase reduced colonies by one-half. Intact sialic acid (residues appear to play an important role in colony formation.
摘要
采用酶处理来测试某些表面肽和碳水化合物在造血脾集落形成中的功能。蛋白酶和大多数糖苷酶对脾集落形成没有影响，而用霍乱弧菌神经氨酸酶处理可使集落减少一半。完整的唾液酸（残基）似乎在集落形成中起重要作用。
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