Hiroi N, White N M
Department of Psychology, McGill University, Montreal, Que., Canada.
Neurosci Lett. 1993 Jun 25;156(1-2):9-12. doi: 10.1016/0304-3940(93)90426-l.
The present study examined the roles of the ventral pallidum area, one output system of the nucleus accumbens, in the acquisition and expression of the amphetamine conditioned place preference (CPP). Pre-conditioning NMDA lesions of the ventral pallidum area completely abolished the acquisition of the CPP. By contrast, post-conditioning NMDA lesions of the same area had no effect on the expression of the CPP. These results suggest that the ventral pallidum area mediates some process that involves the primary, but not conditioned rewarding effects of amphetamine.
本研究考察了伏隔核的一个输出系统——腹侧苍白球区域在苯丙胺条件性位置偏爱（CPP）的获得和表达中的作用。对腹侧苍白球区域进行预处理性NMDA损伤完全消除了CPP的获得。相比之下，对同一区域进行后处理性NMDA损伤对CPP的表达没有影响。这些结果表明，腹侧苍白球区域介导了一些涉及苯丙胺的主要奖赏效应而非条件性奖赏效应的过程。
