改良RAST与Pharmacia CAP系统诊断特征的比较研究
A comparative study of the diagnostic characteristics of the modified RAST and Pharmacia CAP System.
作者信息
Nalebuff D J, Fadal R G, May B C
机构信息
New Jersey College of Medicine and Dentistry, Teaneck.
出版信息
Otolaryngol Head Neck Surg. 1993 Sep;109(3 Pt 2):601-5.
New in vitro technology for the detection of allergen-specific IgE antibody continues to be developed. The manufacturer of one such system, the Pharmacia CAP System, claims that it has test qualities similar to those of the modified RAST. To evaluate this assertion we compared the results obtained with 12 allergens by both procedures on six negative control sera and four sera obtained from atopic patients; a total of 120 tests were performed. The data suggest that attempts to match the sensitivity of the modified RAST are accompanied by a significant loss in test specificity in the Pharmacia CAP System.
用于检测变应原特异性IgE抗体的新型体外技术仍在不断研发。一种此类系统（Pharmacia CAP系统）的制造商声称，其检测质量与改良的放射变应原吸附试验（RAST）相似。为评估这一说法，我们采用这两种方法，对6份阴性对照血清和4份来自特应性患者的血清检测12种变应原；共进行了120次检测。数据表明，在Pharmacia CAP系统中，试图匹配改良RAST的灵敏度时，检测特异性会显著降低。
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