急性创伤性脊髓损伤患者深静脉血栓形成与异位骨化之间的关联。

The association between deep venous thrombosis and heterotopic ossification in patients with acute traumatic spinal cord injury.

作者信息

Colachis S C, Clinchot D M

机构信息

Department of Physical Medicine and Rehabilitation, Ohio State University, Columbus 43210.

出版信息

Paraplegia. 1993 Aug;31(8):507-12. doi: 10.1038/sc.1993.82.

DOI:10.1038/sc.1993.82

PMID:8414634

Abstract

The medical records of 209 patients with acute traumatic spinal cord injury (SCI) admitted to the SCI rehabilitation unit from 7/1/88 through 12/31/92 were reviewed. Whereas the incidence of heterotopic ossification (HO) and deep venous thrombosis (DVT) in this population were 16.7% and 14.3%, respectively, 36.6% of the individuals with DVT had HO. 31.4% of those with HO developed DVT at some time during their acute or rehabilitation hospitalization. The overall incidence of coexistent DVT and HO was 5.3%. The correlation between the occurrence of HO and DVT in this SCI population reached statistical significance (chi 2 = 9.97; p < 0.005). The results of this study suggest that there exists an association between the occurrence of DVT and HO following traumatic SCI. We hypothesize that venous compression from expanding heterotopic bone can result in lower limb DVT following traumatic SCI.

摘要

回顾了1988年7月1日至1992年12月31日期间收治到脊髓损伤康复科的209例急性创伤性脊髓损伤（SCI）患者的病历。该人群中异位骨化（HO）和深静脉血栓形成（DVT）的发生率分别为16.7%和14.3%，而患有DVT的个体中有36.6%发生了HO。HO患者中有31.4%在急性或康复住院期间的某个时间发生了DVT。DVT和HO并存的总体发生率为5.3%。该SCI人群中HO和DVT发生之间的相关性达到统计学显著性（卡方=9.97；p<0.005）。本研究结果表明，创伤性SCI后DVT和HO的发生之间存在关联。我们推测，异位骨生长导致的静脉受压可引起创伤性SCI后的下肢DVT。