MacLennan A H, Green R C
Lancet. 1979 Jan 20;1(8108):117-9. doi: 10.1016/s0140-6736(79)90515-4.
A randomised double-blind trial was done to determine the effect on cervical ripening of 50 mg intravaginal prostaglandin F2 alpha (P.G.F.2 alpha) in a methyl cellulose gel given on the evening before surgical induction of labour. Patients were given either placebo or P.G.F.2 alpha and in both groups cervical stretching and sweeping of the fetal membranes was attempted. Of the 40 control patients, 3 had gone into labour and the mean improvement in the cervical score was 1.6 before surgical induction the next morning. However, 20 of the 40 patients receiving P.G.F.2 alpha went into labour before the proposed induction and the mean change in cervical score (5.1) was significantly greater than that in the placebo group. Of the 40 patients pretreated with P.G.F.2 alpha, 37 had improved cervical scores and significantly fewer required augmentation in labour with intravenous oxytocin than in the control group. No side-effects were experienced and the patients found the treatment acceptable.
进行了一项随机双盲试验，以确定在引产手术前一晚给予含50毫克阴道内前列腺素F2α（P.G.F.2α）的甲基纤维素凝胶对宫颈成熟的影响。患者被给予安慰剂或P.G.F.2α，两组均尝试进行宫颈扩张和胎膜清扫。40名对照患者中，3人自然分娩，次日上午手术引产时宫颈评分平均改善1.6。然而，40名接受P.G.F.2α治疗的患者中有20人在预定引产之前自然分娩，宫颈评分的平均变化（5.1）显著大于安慰剂组。在40名接受P.G.F.2α预处理的患者中，37人宫颈评分得到改善，与对照组相比，需要静脉滴注催产素加强宫缩的患者明显减少。未出现副作用，患者认为该治疗可接受。
