醋酸甲羟孕酮对家兔、大鼠和小鼠的产前毒性。

Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice.

作者信息

Andrew F D, Staples R E

出版信息

Teratology. 1977 Feb;15(1):25-32. doi: 10.1002/tera.1420150104.

DOI:10.1002/tera.1420150104

Abstract

Medroxyprogesterone acetate (MPA) was given once daily sc at 0.1-3,000 mg/kg/day for 3, 6, or 9 consecutive days during gestation days 7 to 15 to CD1 and A/J mice, and New Zealand (NZ) and Dutch Belted (DB) rabbits, and during days 8 to 16 to CD rats. Malformations attributable to MPA did not occur in fetuses of mice or rats exposed to the largest dosage tested. However, 1, 3, or 10 mg/kg on days 13 to 15 to NZ rabbits resulted in 6, 28, and 42% cleft palate, respectively. Comparable cleft palate frequencies were seen in DB offspring.

摘要

在妊娠第7至15天，对CD1和A/J小鼠、新西兰（NZ）兔和荷兰带兔（DB），每天一次皮下注射醋酸甲羟孕酮（MPA），剂量为0.1 - 3000 mg/kg/天，连续注射3、6或9天；对CD大鼠，在妊娠第8至16天进行同样处理。暴露于最大测试剂量的小鼠或大鼠胎儿未出现归因于MPA的畸形。然而，在妊娠第13至15天给NZ兔注射1、3或10 mg/kg，分别导致6%、28%和42%的腭裂。在DB兔后代中观察到了类似的腭裂频率。