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1
Stability, structure and complexity of yeast chromosome III.酵母三号染色体的稳定性、结构与复杂性
Nucleic Acids Res. 1993 Sep 11;21(18):4239-45. doi: 10.1093/nar/21.18.4239.
2
Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae.酿酒酵母第六条染色体的核苷酸序列分析。
Nat Genet. 1995 Jul;10(3):261-8. doi: 10.1038/ng0795-261.
3
DNA helical stability accounts for mutational defects in a yeast replication origin.DNA螺旋稳定性导致酵母复制起点的突变缺陷。
Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2654-8. doi: 10.1073/pnas.89.7.2654.
4
Regional base composition variation along yeast chromosome III: evolution of chromosome primary structure.酵母三号染色体上的区域碱基组成变化：染色体一级结构的进化
Nucleic Acids Res. 1993 Jan 25;21(2):179-83. doi: 10.1093/nar/21.2.179.
5
Colocalization of centromeric and replicative functions on autonomously replicating sequences isolated from the yeast Yarrowia lipolytica.从解脂耶氏酵母中分离出的自主复制序列上着丝粒功能与复制功能的共定位。
Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4912-6. doi: 10.1073/pnas.90.11.4912.
6
TA-repeat microsatellites are closely associated with ARS consensus sequences in yeast chromosome III.TA 重复微卫星与酵母三号染色体中的自主复制序列（ARS）共有序列密切相关。
Yeast. 1993 Jul;9(7):753-9. doi: 10.1002/yea.320090709.
7
DNA deformability changes of single base pair mutants within CDE binding sites in S. Cerevisiae centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries.酿酒酵母着丝粒DNA中CDE结合位点内单碱基对突变体的DNA可变形性变化与测量的染色体丢失率和CDE结合位点对称性相关。
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8
Ease of DNA unwinding is a conserved property of yeast replication origins.DNA解旋的容易程度是酵母复制起点的一个保守特性。
Nucleic Acids Res. 1993 Feb 11;21(3):555-60. doi: 10.1093/nar/21.3.555.
9
DNA fragments isolated from the left end of chromosome III in yeast are repaired to generate functional telomeres.从酵母染色体 III 的左端分离的 DNA 片段被修复以产生功能端粒。
Genome. 1988 Oct;30(5):758-765. doi: 10.1139/g88-123.
10
All 16 centromere DNAs from Saccharomyces cerevisiae show DNA curvature.来自酿酒酵母的所有16种着丝粒DNA均表现出DNA弯曲。
Nucleic Acids Res. 1999 Mar 15;27(6):1444-9. doi: 10.1093/nar/27.6.1444.

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The Genomic HyperBrowser: inferential genomics at the sequence level.基因组超浏览器：序列水平的推理基因组学。
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A stitch in time: efficient computation of genomic DNA melting bubbles.及时一针：基因组DNA解链泡的高效计算
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3
The human genomic melting map.人类基因组熔解图谱。
PLoS Comput Biol. 2007 May;3(5):e93. doi: 10.1371/journal.pcbi.0030093. Epub 2007 Apr 11.
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Through a genome, darkly: comparative analysis of plant chromosomal DNA.透过基因组的迷雾：植物染色体DNA的比较分析
Plant Mol Biol. 2002 Jan;48(1-2):5-20.
5
Distribution of topoisomerase II-mediated cleavage sites and relation to structural and functional landmarks in 830 kb of Drosophila DNA.果蝇830千碱基DNA中拓扑异构酶II介导的切割位点分布及其与结构和功能标记的关系。
Nucleic Acids Res. 1997 Jun 1;25(11):2041-6. doi: 10.1093/nar/25.11.2041.
6
Constraints on mutability in a multiallelic gene family.多等位基因家族中突变可能性的限制因素。
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本文引用的文献

1
Assessments of DNA inhomogeneities in yeast chromosome III.酵母三号染色体中DNA不均匀性的评估。
Nucleic Acids Res. 1993 Feb 11;21(3):703-11. doi: 10.1093/nar/21.3.703.
2
Ease of DNA unwinding is a conserved property of yeast replication origins.DNA解旋的容易程度是酵母复制起点的一个保守特性。
Nucleic Acids Res. 1993 Feb 11;21(3):555-60. doi: 10.1093/nar/21.3.555.
3
Regional base composition variation along yeast chromosome III: evolution of chromosome primary structure.酵母三号染色体上的区域碱基组成变化：染色体一级结构的进化
Nucleic Acids Res. 1993 Jan 25;21(2):179-83. doi: 10.1093/nar/21.2.179.
4
A short chromosomal region with major roles in yeast chromosome III meiotic disjunction, recombination and double strand breaks.一个在酵母III号染色体减数分裂分离、重组和双链断裂中起主要作用的短染色体区域。
Genetics. 1993 Feb;133(2):159-69. doi: 10.1093/genetics/133.2.159.
5
Meiotic nondisjunction and recombination of chromosome III and homologous fragments in Saccharomyces cerevisiae.酿酒酵母中第三条染色体及同源片段的减数分裂不分离与重组
Genetics. 1993 Feb;133(2):149-58. doi: 10.1093/genetics/133.2.149.
6
The effect on chromosome stability of deleting replication origins.删除复制起点对染色体稳定性的影响。
Mol Cell Biol. 1993 Jan;13(1):391-8. doi: 10.1128/mcb.13.1.391-398.1993.
7
Prediction of melting profiles and local helix stability for sequenced DNA.对测序DNA的解链曲线和局部螺旋稳定性的预测。
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8
Influence of base-pair changes and cooperativity parameters on the melting curves of short DNAs.碱基对变化和协同性参数对短DNA熔解曲线的影响。
Biopolymers. 1983 May;22(5):1409-25. doi: 10.1002/bip.360220512.
9
Variation of double-helix stability along DNA molecular thread and its biological implications: homostabilizing propensity of gene double-helix.DNA分子链上双螺旋稳定性的变化及其生物学意义：基因双螺旋的同稳定倾向
Prog Clin Biol Res. 1985;172A:37-46.
10
Estimation of wedge components in curved DNA.弯曲DNA中楔形组件的估计。
Nature. 1987;326(6114):720-2. doi: 10.1038/326720a0.

酵母三号染色体的稳定性、结构与复杂性

Stability, structure and complexity of yeast chromosome III.

作者信息

King G J

机构信息

Breeding and Genetics Department, Horticulture Research International, Wellesbourne, Warwick, UK.

出版信息

Nucleic Acids Res. 1993 Sep 11;21(18):4239-45. doi: 10.1093/nar/21.18.4239.

DOI:10.1093/nar/21.18.4239
PMID:8414978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC310056/
Abstract

The complete sequence of yeast chromosome III provides a model for studies relating DNA sequence and structure at different levels of organisation in eukaryotic chromosomes. DNA helical stability, intrinsic curvature and sequence complexity have been calculated for the complete chromosome. These features are compartmentalised at different levels of organisation. Compartmentalisation of thermal stability is observed from the level delineating coding/non-coding sequences, to higher levels of organisation which correspond to regions varying in G + C content. The three-dimensional path reveals a symmetrical structure for the chromosome, with a densely packed central region and more diffuse and linear subtelomeric regions. This interspersion of regions of high and low curvature is reflected at lower levels of organisation. Complexity of n-tuplets (n = 1 to 6) also reveals compartmentalisation of the chromosome at different levels of organisation, in many cases corresponding to the structural features. DNA stability, conformation and complexity delineate telomeres, centromere, autonomous replication sequences (ARS), transposition hotspots, recombination hotspots and the mating-type loci.

摘要

酵母三号染色体的完整序列为研究真核染色体不同组织水平上的DNA序列与结构之间的关系提供了一个模型。已对完整染色体的DNA螺旋稳定性、固有曲率和序列复杂性进行了计算。这些特征在不同的组织水平上被分隔开来。从界定编码/非编码序列的水平到对应于G + C含量不同区域的更高组织水平，均观察到热稳定性的分隔。三维路径显示出染色体具有对称结构，中央区域紧密堆积，而亚端粒区域更弥散且呈线性。高曲率和低曲率区域的这种散布在较低组织水平上也有所体现。n联体（n = 1至6）的复杂性同样揭示了染色体在不同组织水平上的分隔，在许多情况下与结构特征相对应。DNA稳定性、构象和复杂性界定了端粒、着丝粒、自主复制序列（ARS）、转座热点、重组热点以及交配型基因座。