用硫唑嘌呤和水杨酸钠治疗的大鼠心脏同种异体移植的存活情况。
Survival of heart allografts in rats treated with azathioprine and sodium salicylate.
作者信息
Jamieson S W, Burton N A, Reitz B A, Stinson E B
出版信息
Lancet. 1979 Jan 20;1(8108):130-1. doi: 10.1016/s0140-6736(79)90520-8.
In a rat heart transplant model representing a severe mismatch, median survival time (M.S.T.) with no treatment was 6 days. M.S.T. with azathioprine was 6 days, and with azathioprine and methylprednisolone 7 days. Azathioprine with promethazine hydrochloride gave an M.S.T. of 15 days. In rats treated with sodium salicylate alone M.S.T. was 16 days, and when azathioprine was administered for 12 days in a group continuously treated with sodium salicylate, all hearts were beating normally at 50 days.
在一个代表严重不匹配的大鼠心脏移植模型中，未经治疗时的中位生存时间（M.S.T.）为6天。使用硫唑嘌呤时M.S.T.为6天，使用硫唑嘌呤和甲基强的松龙时为7天。硫唑嘌呤与盐酸异丙嗪联用的M.S.T.为15天。单独使用水杨酸钠治疗的大鼠M.S.T.为16天，而在一组持续用水杨酸钠治疗的大鼠中，硫唑嘌呤给药12天，所有心脏在50天时仍正常跳动。
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