Gibbs A R
Thorax. 1977 Feb;32(1):71-9. doi: 10.1136/thx.32.1.71.
A case of lymphomatoid granulomatosis of the lung is described in which the presenting features were a skin eruption and peripheral neuropathy. The onset of the pulmonary symptoms of breathlessness and productive cough was delayed nine months but, when apparent, the extent of the radiological changes contrasted with the mildness of the symptoms and the triviality of the physical signs. Biopsy of the affected lung revealed a mixed lymphocytic, plasma cell, and histiocytic infiltrate following a perivascular distribution. This combination of clinical and pathological findings is in every detail that of lymphomatoid granulomatosis as recently identified by Liebow et al. (1972). Additional, previously undescribed, and unexplained findings in this case were persistent hypercalciuria and the presence in three axillary lymph nodes of subcapsular groups of cells resembling those of a benign naevus. This is the first case described in the British literature, and it is important that more cases be reported in order that the prevalence, prognosis, and aetiology of the condition should be further established.
本文描述了一例肺部淋巴瘤样肉芽肿病，其首发症状为皮肤疹和周围神经病变。呼吸困难和咳痰性咳嗽等肺部症状在九个月后才出现，然而，当症状明显时，放射学改变的程度与症状的轻微程度及体征的不明显形成了反差。对受累肺部进行活检显示，血管周围分布有混合性淋巴细胞、浆细胞和组织细胞浸润。临床和病理检查结果的这种组合与利博等人（1972年）最近确定的淋巴瘤样肉芽肿病的特征完全相符。该病例还有一些此前未描述且无法解释的额外发现，即持续性高钙尿症以及三个腋窝淋巴结中出现类似良性痣细胞的被膜下细胞群。这是英国文献中报道的首例病例，重要的是应报告更多病例，以便进一步明确该病的患病率、预后和病因。
