Hooson J, Grasso P
Toxicology. 1977 Feb;7(1):1-10. doi: 10.1016/0300-483x(77)90032-4.
Mass cultures of primary rat kidney cells were exposed briefly to aqueous solutions of 20 chemicals and their subsequent growth rate and mitotic activity measured. Proximate carcinogens, and some chemicals with a defined inhibitory action biochemically, depressed the growth and division of the cultures. Non-carcinogenic compounds and precarcinogens did not interfere with the subsequent growth rate and mitotic activity of the cultures. It is suggested that the possession of growth inhibitory properties could give an indication of the carcinogenic activity of a chemical on a short-term basis.
将原代大鼠肾细胞的大量培养物短暂暴露于20种化学物质的水溶液中，然后测量其随后的生长速率和有丝分裂活性。近致癌物以及一些在生物化学上具有明确抑制作用的化学物质，会抑制培养物的生长和分裂。非致癌化合物和前致癌物不会干扰培养物随后的生长速率和有丝分裂活性。有人提出，具有生长抑制特性可能在短期内表明一种化学物质的致癌活性。
