Allen D L, Renner K J, Luine V N
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021.
Pharmacol Biochem Behav. 1993 Aug;45(4):837-41. doi: 10.1016/0091-3057(93)90129-h.
The effect of intrahypothalamic infusion of the monoamine oxidase inhibitor pargyline on lordosis behavior and monamine levels in the preoptic area and hypothalamus was examined. Progesterone-facilitated lordosis was blocked by pargyline in half the treated rats. The inhibition of lordosis was correlated with increases in serotonin and dopamine levels in the ventromedial nucleus of the hypothalamus and serotonin levels in the arcuate nucleus-median eminence when compared to controls or pargyline-treated rats with high levels of lordosis responding. Changes in norepinephrine levels were not correlated with changes in behavior. The results provide further evidence for an inhibitory role of basomedial hypothalamic serotonin in the control of female sexual behavior.
研究了下丘脑内注入单胺氧化酶抑制剂帕吉林对脊柱前凸行为以及视前区和下丘脑单胺水平的影响。在一半接受治疗的大鼠中，帕吉林阻断了孕酮促进的脊柱前凸。与对照组或对帕吉林治疗反应良好且脊柱前凸水平较高的大鼠相比，脊柱前凸的抑制与下丘脑腹内侧核中血清素和多巴胺水平的升高以及弓状核 - 正中隆起中血清素水平的升高相关。去甲肾上腺素水平的变化与行为变化无关。这些结果为下丘脑基底内侧血清素在控制雌性性行为中的抑制作用提供了进一步的证据。
