Hagan M M, Moss D E
Department of Psychology, University of Texas, El Paso 79968-0553.
Pharmacol Biochem Behav. 1993 Aug;45(4):941-4. doi: 10.1016/0091-3057(93)90144-i.
Central injection of peptide YY (PYY) elicits a powerful feeding response with a short latency in satiated rats. Because of this effect, PYY has been implicated as a neurochemical signal in bulimia nervosa. Serotonin agonists and opioid antagonists induce anorectic effects upon feeding behavior in humans and animals. Therefore, to investigate a possible interaction between PYY-induced eating and these anorexigenic agents rats were given injections of either naloxone (100 micrograms/3 microliters, ICV, and 10 mg/kg, SC), fluoxetine (3-30 micrograms/3 microliters and 5-10 mg/kg, IP), or clomipramine (3-30 micrograms/3 microliters and 5-10 mg/kg, IP) prior to fourth ventricular injections of PYY (15 micrograms/18 microliters). Central and peripheral naloxone and IP but not central injections of fluoxetine blocked PYY-induced intake. Clomipramine had no effect. This suggests that PYY-stimulated feeding may require the action of endogenous opioids and may be inhibited by serotonergic function.
向饱足的大鼠脑室内注射肽YY（PYY）会在短时间内引发强烈的进食反应。由于这种效应，PYY被认为是神经性贪食症中的一种神经化学信号。血清素激动剂和阿片类拮抗剂会对人和动物的进食行为产生厌食作用。因此，为了研究PYY诱导的进食与这些厌食剂之间可能存在的相互作用，在向大鼠第四脑室注射PYY（15微克/18微升）之前，给大鼠注射纳洛酮（100微克/3微升，脑室内注射，以及10毫克/千克，皮下注射）、氟西汀（3 - 30微克/3微升和5 - 10毫克/千克，腹腔注射）或氯米帕明（3 - 30微克/3微升和5 - 10毫克/千克，腹腔注射）。脑室内和外周注射纳洛酮以及腹腔注射氟西汀（而非脑室内注射氟西汀）可阻断PYY诱导的进食。氯米帕明没有效果。这表明PYY刺激的进食可能需要内源性阿片类物质的作用，并且可能受到血清素功能的抑制。
