硫代酰胺，一种组胺H3受体拮抗剂，能有效抑制大鼠体内肽YY诱导的食物摄入。

Thioperamide, a histamine H3 receptor antagonist, powerfully suppresses peptide YY-induced food intake in rats.

作者信息

Itoh E, Fujimiya M, Inui A

机构信息

Pharmaceutical Research Department, Ube Research Lab, Japan.

出版信息

Biol Psychiatry. 1999 Feb 15;45(4):475-81. doi: 10.1016/s0006-3223(98)00044-4.

DOI:10.1016/s0006-3223(98)00044-4

PMID:10071721

Abstract

BACKGROUND

Whether or not peptide YY (PYY)-induced hyperphagia is modified by the histaminergic system in the brain is not yet known.

METHODS

We investigated the effect on feeding of intracerebroventricular (ICV) administration of a specific histamine H3 receptor antagonist prior to ICV administration of PYY in rats.

RESULTS

PYY (1, 3, and 10 micrograms/10 microL) strongly induced feeding behavior in a dose-dependent manner in sated rats. The 4-hour food intake induced by 3 micrograms/10 microL of PYY was equal to that induced by a 16-hour fast. The ICV administration of thioperamide (40.8, 122.4, and 408.5 micrograms/10 microL) did not suppress the 4-hour food intake induced by 16-hour fasting; however, thioperamide produced dose-dependent and strong inhibition of hyperphagia induced by a 3-microgram dose of PYY.

CONCLUSIONS

These results suggest that the effect of PYY on appetite is different than that induced by fasting and may involve a histaminergic mechanism.

摘要

背景

大脑中的组胺能系统是否会改变肽YY（PYY）诱导的摄食过多现象尚不清楚。

方法

我们研究了在大鼠脑室内（ICV）注射PYY之前，预先脑室内注射一种特定的组胺H3受体拮抗剂对摄食的影响。

结果

PYY（1、3和10微克/10微升）以剂量依赖的方式强烈诱导饱食大鼠的摄食行为。3微克/10微升的PYY诱导的4小时食物摄入量与16小时禁食诱导的摄入量相当。脑室内注射硫代哌啶（40.8、122.4和408.5微克/10微升）并未抑制16小时禁食诱导的4小时食物摄入量；然而，硫代哌啶对3微克剂量的PYY诱导的摄食过多产生了剂量依赖性的强烈抑制作用。