Schärer K
Toxicology. 1977 Feb;7(1):45-56. doi: 10.1016/0300-483x(77)90037-3.
Growing male rats were kept on a restricted feed intake. After 13 weeks they reached a final body weight of 250 g in comparison with 366 g of their ad lib. fed controls. The relative weights of the heart, kidneys, spleen, pituitary and prostate/seminal vesicle were not altered by underfeeding. The relative weights of the brain, adrenals and tests were increased by 30 to 40% in the feed-restricted groups, the thyroid by about 20%. The relative weight of the liver was decreased by about 30%. When growth is markedly reduced in a toxicity experiment alterations of this kind in the organ weight: body weight ratios have to be expected as a physiological response of the organism to decreased feed intake. They must be differentiated from organ weight changes resulting from primary toxic influences of the drug tested.
对生长中的雄性大鼠进行限食。13周后，它们的最终体重达到250克，而自由采食的对照组大鼠体重为366克。限食并未改变心脏、肾脏、脾脏、垂体以及前列腺/精囊的相对重量。限食组大鼠大脑、肾上腺和睾丸的相对重量增加了30%至40%，甲状腺相对重量增加了约20%。肝脏的相对重量减少了约30%。在毒性实验中，当生长明显受到抑制时，作为机体对摄食量减少的生理反应，预计会出现这种器官重量与体重比值的变化。必须将它们与受试药物的原发性毒性影响所导致的器官重量变化区分开来。
