Means L W, Higgins J L, Fernandez T J
Department of Psychology, East Carolina University, Greenville, NC 27858-4353.
Physiol Behav. 1993 Sep;54(3):503-8. doi: 10.1016/0031-9384(93)90243-9.
Fourteen-month-old C57BL/6 (NIA) mice were placed on a nutritionally complete diet providing 139.4 kcal/week. Over a 2-month period the food ration of experimental mice (AE) was reduced to 85 kcal/week, where it remained for the duration of the study. An aged control group (AC) continued with the higher calorie diet. At age 22 months, AC mice and half of the AE mice (AE22) were given a battery of behavioral tests. The remaining AE mice (AE25) were given the test battery at age 25 months. Also, a middle-aged control group (MC) was tested at age 13 months. Midlife onset caloric restriction (CR) increased longevity and preserved strength, coordination, and spontaneous alternation behavior, and altered responses to enclosed alleys. A spatial discrimination in the Morris water maze and a spatial delayed matching-to-sample water-escape task were insensitive to age and diet. The aged mice were adversely affected by testing.
将14个月大的C57BL/6（NIA）小鼠置于营养完全的饮食中，每周提供139.4千卡热量。在2个月的时间里，实验小鼠（AE）的食物配给量减少到每周85千卡，并在研究期间保持不变。老年对照组（AC）继续采用高热量饮食。在22个月大时，对AC小鼠和一半的AE小鼠（AE22）进行了一系列行为测试。其余的AE小鼠（AE25）在25个月大时进行测试。此外，中年对照组（MC）在13个月大时进行测试。中年开始的热量限制（CR）可延长寿命，并保持力量、协调性和自发交替行为，同时改变对封闭通道的反应。莫里斯水迷宫中的空间辨别和空间延迟匹配样本水逃避任务对年龄和饮食不敏感。测试对老年小鼠产生了不利影响。
