Gonzalez-Lima F, Helmstetter F J, Agudo J
Department of Psychology, University of Texas, Austin 78712.
Physiol Behav. 1993 Sep;54(3):605-12. doi: 10.1016/0031-9384(93)90256-f.
Autoradiographic techniques using the radiolabeled glucose analog [14C]2-fluoro-2-deoxy-D-glucose (FDG) were used to map the functional activity in the CNS during drinking behavior. Rats were trained to drink water during a 1-h session each day. Half of the rats were injected with FDG and allowed to drink, while the other half were satiated prior to FDG injection. Uptake of FDG for drinking and control groups of rats was quantified in 60 brain structures from frontal cortex to cervical spinal cord. The largest percent increase in activity (96%) during drinking was in the lateral hypothalamus. Limbic structures with significant metabolic increases included the lateral septum (48%), lateral habenula (44%), and nucleus accumbens (32%). Thalamic nuclei activated included intralaminar (60%), zona incerta (51%), ventroposteromedial (50%), anterior ventral (47%), and dorsal medial (40%). Other structures with increases were the caudal caudate nucleus (53%) and the spinal trigeminal nucleus (45%). The findings were interpreted in light of related metabolic mapping studies of the effects of orofacial stimulation, dehydration, ingestion, arousal, and reward. It was concluded that this FDG study revealed primarily the involvement of structures linked to rewarding and arousal components of motivated drinking behavior, as well as sensorimotor correlates of the orofacial stimulation. The findings provide the first comprehensive functional map of brain systems related to drinking behavior in adult animals.
利用放射性标记的葡萄糖类似物[14C]2-氟-2-脱氧-D-葡萄糖（FDG）的放射自显影技术，来绘制饮水行为期间中枢神经系统的功能活动图。大鼠每天接受1小时的饮水训练。一半的大鼠注射FDG后饮水，而另一半在注射FDG之前已处于饱腹状态。对大鼠饮水组和对照组的60个脑结构中FDG的摄取进行了定量分析，这些脑结构从额叶皮质到颈脊髓。饮水期间活动增加百分比最大的是下丘脑外侧区（96%）。代谢显著增加的边缘系统结构包括外侧隔核（48%）、外侧缰核（44%）和伏隔核（32%）。被激活的丘脑核团包括板内核（60%）、未定带（51%）、腹后内侧核（50%）、腹前核（47%）和背内侧核（40%）。其他活动增加的结构是尾状核尾部（53%）和三叉神经脊束核（45%）。根据对口面部刺激、脱水、摄食、觉醒和奖赏效应的相关代谢图谱研究对这些发现进行了解释。得出的结论是，这项FDG研究主要揭示了与动机性饮水行为的奖赏和觉醒成分相关的结构的参与，以及口面部刺激的感觉运动相关性。这些发现提供了成年动物与饮水行为相关的脑系统的首张全面功能图谱。
