Kogelnik H D
Strahlentherapie. 1977 Mar;153(3):163-7.
A comparative analysis of 1286 patients with squamous cell carcinomas of the upper respiratory and digestive tracts successfully treated either by surgery, irradiation or a combination of both showed that the incidence of new (second) lesions in these regions is practically identical with the different treatment modalities up to 25 years following treatment. Only within five years following surgery the incidence of new cancers in the vicinity of the original cancer is statistically significantly higher than in patients treated by irradiation alone or in combination with surgery. This is explained by probable eradication of in situ carcinomas or microscopic foci of invasive cancer located in the vicinity and hence receiving a significant dose of irradiation. These new (second) lesions occur about 1000 times more frequently than it would be expected from the estimated cancer-incidence in these sites and are to be separated from the extremely rare therapeutically induced malignancies.
对1286例上呼吸道和消化道鳞状细胞癌患者进行的比较分析显示，这些患者分别通过手术、放疗或两者联合治疗且治疗成功，在治疗后的25年内，这些区域新（第二）病变的发生率与不同治疗方式基本相同。仅在手术后的五年内，原发癌附近新癌症的发生率在统计学上显著高于仅接受放疗或放疗联合手术治疗的患者。这可以解释为可能根除了位于附近的原位癌或浸润癌的微小病灶，因此接受了大剂量的放疗。这些新（第二）病变的发生频率比根据这些部位估计的癌症发病率预期的要高约1000倍，并且应与极其罕见的治疗性诱发恶性肿瘤区分开来。
