Ferrer I, Isamat F, López-Obarrio L, Conesa G, Rimbau J, Alcántara S, Español I, Zújar M J
Unit of Neuropathology, Hospital de Bellvitge Príncipes de España, University of Barcelona, Spain.
J Neurosurg. 1993 Jan;78(1):133-7. doi: 10.3171/jns.1993.78.1.0133.
Calbindin D-28K and parvalbumin immunocytochemistry were used in the study of central ganglionic cell tumors. Most neurons in the ganglioglioma were immunoreactive to calbindin D-28K, but a few cells were labeled with antibodies against parvalbumin. In contrast, most cells in dysplastic gangliocytoma of the cerebellum were parvalbumin immunoreactive, but fewer reacted with anti-calbindin antibodies. These latter cells had two or three dendrites with claw-shaped terminals and axons with recurrent collateral branches and varicose terminals filled with strings and buttons. These observations suggest that central ganglionic cell tumors, including dysplastic gangliocytoma of the cerebellum, are composed of neurons which, on the basis of their calcium-binding protein content, have particular metabolic and electrophysiological properties.
钙结合蛋白D-28K和小白蛋白免疫细胞化学被用于中枢神经节细胞瘤的研究。大多数神经节胶质瘤中的神经元对钙结合蛋白D-28K呈免疫反应性，但少数细胞被抗小白蛋白抗体标记。相比之下，小脑发育异常性神经节细胞瘤中的大多数细胞对小白蛋白呈免疫反应性，但与抗钙结合蛋白抗体反应的细胞较少。这些后者的细胞有两到三个带有爪状终末的树突和带有反复侧支及充满串珠和纽扣状曲张终末的轴突。这些观察结果表明，包括小脑发育异常性神经节细胞瘤在内的中枢神经节细胞瘤由神经元组成，基于其钙结合蛋白含量，这些神经元具有特定的代谢和电生理特性。
