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Calbindin D-28k and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis.

作者信息

Ferrer I, Tuñón T, Serrano M T, Casas R, Alcántara S, Zújar M J, Rivera R M

机构信息

Depto Anatomía Patológica, Hospital Príncipes de España, Universidad de Barcelona.

出版信息

J Neurol Neurosurg Psychiatry. 1993 Mar;56(3):257-61. doi: 10.1136/jnnp.56.3.257.

DOI:10.1136/jnnp.56.3.257
PMID:8459241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1014857/
Abstract

The morphology and distribution of local-circuit neurons (interneurons) were examined, by calbindin D-28k and parvalbumin immunocytochemistry, in the frontal cortex (area 8) in two patients with frontal lobe dementia of non-Alzheimer type associated with classical amyotrophic lateral sclerosis (ALS), and in seven normal cases. The density of calbindin D-28k immunoreactive cells was dramatically reduced in ALS patients, but the density of parvalbumin-immunoreactive neurons was preserved. Decreased density of calbindin D-28k-immunoreactive neurons, which are mainly located in the upper cortical layers, may interfere with the normal processing of cortico-cortical connections, whereas integrity of parvalbumin-immunoreactive cells may be associated with the preservation of the major inhibitory intracortical circuits in patients with frontal lobe dementia.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42fe/1014857/1287119e1004/jnnpsyc00476-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42fe/1014857/32c5cdab1de0/jnnpsyc00476-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42fe/1014857/1287119e1004/jnnpsyc00476-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42fe/1014857/32c5cdab1de0/jnnpsyc00476-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42fe/1014857/1287119e1004/jnnpsyc00476-0031-a.jpg

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