Rosse W F
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Am J Hematol. 1993 Jan;42(1):122-6. doi: 10.1002/ajh.2830420124.
In recounting the history of the development of knowledge about PNH, the roles of the clinician, the basic scientist, and the clinician-investigator are apparent. Without the observations of the clinicians, the problem could not be posed. Without the contributions from basic science (the biochemistry of complement, the biology of glycosyl-phosphatidylinositol anchors, etc), the information necessary to the solution of the problem would not be available. Without the synthesis of the clinician-investigator, the two elements would not be fused to result in knowledge about the disease.
在讲述阵发性睡眠性血红蛋白尿（PNH）相关知识的发展历程时，临床医生、基础科学家以及临床研究人员所发挥的作用显而易见。若没有临床医生的观察，该问题便无法被提出。若没有基础科学（补体生物化学、糖基磷脂酰肌醇锚定物生物学等）的贡献，解决该问题所需的信息便无从获取。若没有临床研究人员的整合，这两个要素就无法融合从而产生关于该疾病的知识。
