Remy-Jardin M, Remy J, Boulenguez C, Sobaszek A, Edme J L, Furon D
Department of Radiology, Hôpital Calmette CHRU de Lille, France.
Radiology. 1993 Jan;186(1):107-15. doi: 10.1148/radiology.186.1.8416548.
A prospective computed tomographic (CT) study was performed to determine the prevalence of lung changes in smokers. The study group comprised 175 healthy adult volunteers (current smokers, n = 98; ex-smokers, n = 26; nonsmokers, n = 51). The subjects underwent clinical examination, pulmonary function tests, chest radiography, and conventional and high-resolution CT (HRCT). Significant differences between current smokers, ex-smokers, and nonsmokers were observed with HRCT in the identification of subpleural (P = .11) and parenchymal (P < .001) micronodules, emphysema (P < .001), and areas of ground-glass attenuation (P = .0001). All subjects had normal pulmonary function. Parenchymal micronodules, areas of ground-glass attenuation, and emphysema were observed with a significant predominance in the upper lung zones (P < .01). Presence of emphysema and abnormal bronchial wall thickening were the only HRCT signs associated with significantly lower values of functional parameters. These data support the concept that parenchymal abnormalities can be detected in healthy smokers with normal findings at chest radiography and pulmonary function tests.
进行了一项前瞻性计算机断层扫描（CT）研究，以确定吸烟者肺部变化的患病率。研究组包括175名健康成年志愿者（当前吸烟者，n = 98；既往吸烟者，n = 26；非吸烟者，n = 51）。受试者接受了临床检查、肺功能测试、胸部X线摄影以及传统CT和高分辨率CT（HRCT）检查。在通过HRCT识别胸膜下（P = 0.11）和实质（P < 0.001）微小结节、肺气肿（P < 0.001）以及磨玻璃样衰减区域（P = 0.0001）方面，当前吸烟者、既往吸烟者和非吸烟者之间存在显著差异。所有受试者的肺功能均正常。在肺上叶区域观察到实质微小结节、磨玻璃样衰减区域和肺气肿明显占优势（P < 0.01）。肺气肿的存在和支气管壁异常增厚是与功能参数值显著降低相关的仅有的HRCT征象。这些数据支持这样一种观点，即在胸部X线摄影和肺功能测试结果正常的健康吸烟者中可以检测到实质异常。
