Silvergleid A J, Hafleigh E B, Harabin M A, Wolf R M, Grumet F C
Transfusion. 1977 Jan-Feb;17(1):33-7. doi: 10.1046/j.1537-2995.1977.17177128881.x.
In patients with severe allergic reactions to plasma proteins it is possible to observe such reactions to even the small quantity of plasma contained in platelet concentrates. A platelet washing solution was designed, and platelet concentrates for four such patients were washed before infusion. Transfusion reactions were completely eliminated by the washing procedure. Platelet recovery was equivalent to that of unwashed platelets, and hemostatic effectiveness of the infused platelet concentrates was evidenced by abrupt cessation of bleeding episodes, including purpura and hematuria. Platelet washing represents a valuable, rapid and simple approach to the problem patient with thrombocytopenia and severe reactions to plasma proteins.
对于对血浆蛋白有严重过敏反应的患者，即使是血小板浓缩物中所含的少量血浆也可能引发此类反应。设计了一种血小板洗涤溶液，并对四名此类患者的血小板浓缩物在输注前进行了洗涤。通过洗涤程序完全消除了输血反应。血小板回收率与未洗涤的血小板相当，输注的血小板浓缩物的止血效果通过出血症状（包括紫癜和血尿）的突然停止得到证明。血小板洗涤对于患有血小板减少症且对血浆蛋白有严重反应的问题患者而言，是一种有价值、快速且简单的方法。
