胃癌的细胞动力学与预后

Cell kinetics and prognosis in gastric cancer.

作者信息

Amadori D, Bonaguri C, Volpi A, Nanni O, Zoli W, Lundi N, Amadori A, Magni E, Saragoni A

机构信息

Department of Oncology, Morgagni-Pierantoni Hospital, Forli, Italy.

出版信息

Cancer. 1993 Jan 1;71(1):1-4. doi: 10.1002/1097-0142(19930101)71:1<1::aid-cncr2820710102>3.0.co;2-r.

DOI:10.1002/1097-0142(19930101)71:1<1::aid-cncr2820710102>3.0.co;2-r

PMID:8416705

Abstract

METHODS

The potential proliferative activity of primary gastric cancer was determined using the in vitro tritiated thymidine labeling index (LI) technique.

RESULTS

The proliferative rate had a wide range (0.1-28.4%) with a median value of 9.3%. The cell kinetics of the primary tumor were not related to clinicopathologic features, such as the patient's age and sex or the tumor's histologic type and stage. The contribution of cell kinetics to prognosis was investigated in a series of 28 patients (median follow-up, 34 months). The 3-year survival rate was 50% for patients with slowly proliferating tumors compared with only 13% for those with rapidly proliferating tumors. Moreover, in patients with high-LI tumors, the risk of death was more than sixfold greater than for those with low-LI tumors.

CONCLUSIONS

These data suggest that cell kinetic studies might be an important discriminant to predict prognosis in gastric cancer.

摘要

方法

采用体外氚标记胸腺嘧啶核苷标记指数（LI）技术测定原发性胃癌的潜在增殖活性。

结果

增殖率范围较广（0.1 - 28.4%），中位数为9.3%。原发性肿瘤的细胞动力学与临床病理特征无关，如患者的年龄、性别或肿瘤的组织学类型及分期。对28例患者（中位随访时间34个月）进行了细胞动力学对预后影响的研究。肿瘤增殖缓慢的患者3年生存率为50%，而肿瘤增殖快速的患者仅为13%。此外，LI值高的肿瘤患者死亡风险比LI值低的患者高6倍多。