Chow L T, Chow W H
Institute of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Med J Aust. 1993 Jan 4;158(1):48-9. doi: 10.5694/j.1326-5377.1993.tb121652.x.
To present a case of gemfibrozil-induced myositis which precipitated an acute compartment syndrome.
A 49-year-old woman with chronic renal failure was given gemfibrozil for hyperlipidaemia. She developed myositis in the sixth week of therapy. Her symptoms initially persisted despite withdrawal of gemfibrozil and she developed an acute compartment syndrome.
Emergency fasciotomy was performed. She gradually improved and complete recovery occurred eight weeks after cessation of gemfibrozil therapy.
Gemfibrozil may induce a local myositis which, in our patient, precipitated an acute compartment syndrome. One should be alert to symptoms of possible drug-induced myositis in patients receiving gemfibrozil. Extreme caution should be exercised in its use in patients with impaired renal function.
报告一例吉非贝齐诱发的肌炎，该肌炎引发了急性骨筋膜室综合征。
一名49岁慢性肾衰竭女性因高脂血症服用吉非贝齐。治疗第六周时她患上了肌炎。尽管停用了吉非贝齐，她的症状最初仍持续存在，并发展为急性骨筋膜室综合征。
进行了急诊筋膜切开术。她逐渐好转，在停用吉非贝齐治疗八周后完全康复。
吉非贝齐可能诱发局部肌炎，在我们的患者中，该肌炎引发了急性骨筋膜室综合征。对于接受吉非贝齐治疗的患者，应警惕可能由药物诱发的肌炎症状。在肾功能受损的患者中使用该药时应格外谨慎。
