恶性疟原虫裂殖子蛋白——棒状体相关蛋白1和红细胞结合抗原1的特异性T细胞识别
Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum.
作者信息
Jakobsen P H, Hviid L, Theander T G, Afare E A, Ridley R G, Heegaard P M, Stuber D, Dalsgaard K, Nkrumah F K
机构信息
Department of Infectious Diseases, University Hospital, Copenhagen, Denmark.
出版信息
Infect Immun. 1993 Jan;61(1):268-73. doi: 10.1128/iai.61.1.268-273.1993.
Abstract
The merozoite proteins merozoite surface protein 1 (MSP-1) and rhoptry-associated protein 1 (RAP-1) and synthetic peptides containing sequences of MSP-1, RAP-1, and erythrocyte-binding antigen 1, induced in vitro proliferative responses of lymphocytes collected from Ghanaian blood donors living in an area with a high rate of transmission of malaria. Lymphocytes from a large proportion of the Ghanaian blood donors proliferated in response to the RAP-1 peptide, unlike those of Danish control blood donors, indicating that this sequence contains a malaria-specific T-cell epitope broadly recognized by individuals living in an area with a high transmission rate of malaria. Most of the donor plasma samples tested contained immunoglobulin G (IgG) and IgM antibodies recognizing the merozoite proteins, while only a minority showed high IgG reactivity to the synthetic peptides.
摘要
裂殖子蛋白裂殖子表面蛋白1（MSP-1）、棒状体相关蛋白1（RAP-1）以及含有MSP-1、RAP-1和红细胞结合抗原1序列的合成肽，可诱导从生活在疟疾高传播地区的加纳献血者采集的淋巴细胞发生体外增殖反应。与丹麦对照献血者不同，很大比例的加纳献血者的淋巴细胞对RAP-1肽发生增殖反应，这表明该序列包含一个被生活在疟疾高传播地区的个体广泛识别的疟疾特异性T细胞表位。大多数检测的献血者血浆样本含有识别裂殖子蛋白的免疫球蛋白G（IgG）和IgM抗体，而只有少数样本对合成肽表现出高IgG反应性。
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