先天性弓形虫病大鼠模型：三种弓形虫菌株向胎儿的传播率及慢性感染的保护作用
Rat model of congenital toxoplasmosis: rate of transmission of three Toxoplasma gondii strains to fetuses and protective effect of a chronic infection.
作者信息
Zenner L, Darcy F, Cesbron-Delauw M F, Capron A
机构信息
Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France.
出版信息
Infect Immun. 1993 Jan;61(1):360-3. doi: 10.1128/iai.61.1.360-363.1993.
Abstract
The incidence of congenital toxoplasmosis in Fischer rats infected between the 8th and 12th days of pregnancy with three different strains of Toxoplasma gondii (RH, 76K, and Prugniaud) were 58.2, 35.2, and 62.8%, respectively. No infected fetuses were collected from rats previously infected with RH or Prugniaud strain parasites, even if the rats were reinfected during pregnancy. Since pups from chronically infected mothers are protected from congenital toxoplasmosis, rat infection could thus constitute a relevant model for immunological studies and vaccine design.
摘要
在妊娠第8至12天感染三种不同弓形虫菌株（RH、76K和Prugniaud）的Fischer大鼠中，先天性弓形虫病的发病率分别为58.2%、35.2%和62.8%。即使在怀孕期间再次感染，先前感染过RH或Prugniaud株寄生虫的大鼠也未收集到受感染的胎儿。由于慢性感染母亲的幼崽可免受先天性弓形虫病的影响，因此大鼠感染可构成免疫研究和疫苗设计的相关模型。
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