Graham D I, Hay J, Hutchison W M, Siim J C
J Pathol. 1984 Apr;142(4):265-77. doi: 10.1002/path.1711420405.
The brains of mice with congenital ocular toxoplasmosis were examined histologically. Toxoplasma tissue cysts and a subacute/chronic meningo-encephalitis were present in the brains of all infected mice. The findings were very similar to those seen in human congenital toxoplasmosis. The murine model of congenital toxoplasmic encephalitis described in this paper will be valuable in the study of the pathogenesis, natural history and treatment of this condition.
对患有先天性眼弓形虫病的小鼠大脑进行了组织学检查。所有受感染小鼠的大脑中均存在弓形虫组织囊肿和亚急性/慢性脑膜脑炎。这些发现与人类先天性弓形虫病的情况非常相似。本文所述的先天性弓形虫性脑炎小鼠模型在该疾病的发病机制、自然病程及治疗研究中将具有重要价值。
