Brenner H, Siegle S, Stegmaier C, Ziegler H
Universität Ulm, Forschungs- und Geschäftsstelle Epidemiologie, Federal Republic of Germany.
J Cancer Res Clin Oncol. 1993;119(3):179-83. doi: 10.1007/BF01229534.
The occurrence of second primary malignancies was assessed among 2922 women with cervical cancer, 2721 women with endometrial cancer and 1745 women with malignant neoplasms of the ovaries, who were notified to the cancer registry of Saarland, Germany, between 1968 and 1987. Analyses are presented for second primary malignancies at any site and at the most important single sites. Among women with cervical cancer, 98 second primary malignancies were observed, slightly fewer than the 99.3 cases that would have been expected on the basis of the incidence rates of the general population (standardized incidence ratio, SIR = 0.99). More second malignancies were observed than expected in the urinary bladder (SIR = 3.51) while the opposite applied to second neoplasms in the breast (SIR = 0.56). Among women with endometrial and ovarian cancer, the numbers of observed cases slightly exceeded the expected numbers for second primary neoplasms at any site (SIR = 1.19 and 1.41 respectively). More second primary neoplasms were observed than expected in the colon, breast, urinary bladder and kidneys among these women. We discuss our results, which are in agreement with findings among North European and North American populations, from clinical and etiological points of view.
对1968年至1987年间向德国萨尔州癌症登记处报告的2922例宫颈癌女性、2721例子宫内膜癌女性和1745例卵巢恶性肿瘤女性进行了第二原发性恶性肿瘤发生情况的评估。报告了任何部位及最重要的单个部位的第二原发性恶性肿瘤分析结果。在宫颈癌女性中，观察到98例第二原发性恶性肿瘤，略少于根据一般人群发病率预期的99.3例（标准化发病率比，SIR = 0.99）。观察到的膀胱第二恶性肿瘤多于预期（SIR = 3.51），而乳腺第二肿瘤则相反（SIR = 0.56）。在子宫内膜癌和卵巢癌女性中，观察到的病例数略超过任何部位第二原发性肿瘤的预期数（分别为SIR = 1.19和1.41）。在这些女性中，观察到的结肠、乳腺、膀胱和肾脏的第二原发性肿瘤多于预期。我们从临床和病因学角度讨论了我们的结果，这些结果与北欧和北美人群的研究结果一致。
