Nakada T, Kwee I L
Neurochemistry Research Laboratory, Department of Veterans Affairs Medical Center, Martinez, California.
Magn Reson Med. 1993 Jan;29(1):122-4. doi: 10.1002/mrm.1910290122.
31-Phosphorus (31P) nuclear magnetic resonance (NMR) spectroscopy of fetal brain in utero was obtained entirely noninvasively in rat utilizing image selected in vivo spectroscopy (ISIS). The results were in excellent agreement with the data obtained using the surface coil method in the late stage fetus, namely, high phosphomonoester (PME), low phosphocreatine (PCr), and high intracellular pH. Localized spectroscopy provides unprecedented opportunities for the investigation of fetal brain metabolism in utero.
利用体内选择成像光谱法（ISIS），在大鼠体内完全无创地获得了子宫内胎儿大脑的31-磷（31P）核磁共振（NMR）光谱。结果与在晚期胎儿中使用表面线圈法获得的数据高度一致，即高磷酸单酯（PME）、低磷酸肌酸（PCr）和高细胞内pH值。局部光谱学为研究子宫内胎儿脑代谢提供了前所未有的机会。
