Cohen S, Esclamado R M, Telian S, Aloe L, Kileny P
Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor 48109-0312.
Ann Otol Rhinol Laryngol. 1993 Jan;102(1 Pt 1):28-34. doi: 10.1177/000348949310200106.
Exaggeration of normally protective laryngeal reflexes is thought to play a role in several disorders, including the sudden infant death syndrome. An analysis of brain stem neural activity following laryngeal stimulation may provide insight into the pathophysiology of pathologic laryngeal reflexes and help to identify individuals at risk for these disorders. The purpose of this study was to define the far-field brain stem activity following laryngeal stimulation in the porcine model. This activity has been termed the laryngeal brain stem evoked response and may represent a potentially useful and objective measure of the neuronal activity in the laryngeal reflex pathway. Electrical stimulation of the superior laryngeal nerve was performed in 14 mixed-breed piglets under a variety of physiologic conditions. A total of six positive and six negative discrete waves were detected, with mean latencies ranging from 1.24 to 7.16 milliseconds. Stimulations performed during hypoxic, hypercapneic, or hypocapneic conditions resulted in no significant differences in waveform latencies. There appears to be a reproducible, but somewhat variable, brain stem response elicited by superior laryngeal nerve stimulation that can be recorded via a far-field technique in the porcine model.
人们认为，正常保护性喉反射的亢进在包括婴儿猝死综合征在内的多种疾病中起作用。对喉刺激后脑干神经活动的分析可能有助于深入了解病理性喉反射的病理生理学，并有助于识别这些疾病的高危个体。本研究的目的是确定猪模型中喉刺激后的远场脑干活动。这种活动被称为喉脑干诱发反应，可能代表了一种潜在有用且客观的喉反射通路神经元活动测量方法。在14只杂种仔猪的各种生理条件下，对上喉神经进行电刺激。共检测到六个正向和六个负向离散波，平均潜伏期为1.24至7.16毫秒。在缺氧、高碳酸血症或低碳酸血症条件下进行的刺激，波形潜伏期没有显著差异。上喉神经刺激似乎能引发可重复但略有变化的脑干反应，可通过远场技术在猪模型中记录下来。
