Palli D, Decarli A, Cipriani F, Sitas F, Forman D, Amadori D, Avellini C, Giacosa A, Manca P, Russo A
Unità di Epidemiologia, Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy.
Cancer Epidemiol Biomarkers Prev. 1993 Jan-Feb;2(1):37-40.
In a survey of 930 adults aged 35-74 years randomly sampled from the general population of four areas of Italy, two at low and two at high risk for gastric cancer, plasma levels of Helicobacter pylori IgG antibodies were assayed in order to investigate associations with the geographical distribution of gastric cancer and other dietary and life-style factors, as assessed by personal interview. H. pylori positivity (antibody titer above or equal to 10 micrograms/ml), 45% overall, increased with age and was inversely associated with social class but showed little geographical variation or association with dietary variables and blood nutrients. H. pylori positivity was also associated with increased blood levels of pepsinogens, particularly pepsinogen II. The authors discuss these findings in relation to those from a previous case-control study of gastric cancer in the same areas.
在一项从意大利四个地区的普通人群中随机抽取930名35至74岁成年人的调查中，其中两个地区胃癌风险低，两个地区胃癌风险高，检测了血浆中幽门螺杆菌IgG抗体水平，以调查其与胃癌地理分布以及其他饮食和生活方式因素的关联，这些因素通过个人访谈进行评估。幽门螺杆菌阳性（抗体滴度高于或等于10微克/毫升），总体为45%，随年龄增加而升高，与社会阶层呈负相关，但在地理分布上变化不大，与饮食变量和血液营养素也无关联。幽门螺杆菌阳性还与胃蛋白酶原血液水平升高有关，尤其是胃蛋白酶原II。作者将这些发现与之前在同一地区进行的胃癌病例对照研究结果进行了讨论。
