Barsoum A L, Kuwert E K
Z Immunitatsforsch Immunobiol. 1977 Feb;152(5):388-401.
Circulating IgE levels were measured in a non-selected normal population using a solid phase radioimmunoassay (Phadebas Radioimmunosorbenttest "RIST"). The population was divided according to age into 6 subpopulations. Both the main and the subpopulation showed multimodal distributions with 3 maxima of their IgE levels and not a Gaussian distribution. According to the maxima, the multimodal distribution was divided into 3 groups designated AA, Aa and aa. The IgE geometric mean in each group differs statistically significant (p less than 0.01). The proportions of individuals in each group agreed with the theoretical frequencies derived from the Hardy-Weinberg law and with frequencies for atopic (a) and non-atopic (A) alleles (0.152 and 0.846, respectively), as calculated from clinical studies by WIENER et al. (1). After exclusion of Aa and aa individuals from the population the distribution was shown to be normal. The IgE geometric mean in the "net" main population was found to be 33 U/ml. This value is slightly higher than those of recent studies on IgE levels. The mean level of IgE in the different age-groups did not vary significantly from that of the main population although a tendency for a decrease of IgE levels with increasing age was noticeable.
使用固相放射免疫测定法（法德巴斯放射免疫吸附试验“RIST”）在未经过筛选的正常人群中测量循环免疫球蛋白E（IgE）水平。根据年龄将该人群分为6个亚组。主要人群和亚组均呈现多峰分布，其IgE水平有3个峰值，而非高斯分布。根据峰值，多峰分布被分为3组，分别命名为AA、Aa和aa。每组的IgE几何平均值在统计学上有显著差异（p小于0.01）。每组个体的比例与哈迪-温伯格定律推导的理论频率以及特应性（a）和非特应性（A）等位基因的频率一致（分别为0.152和0.846），这是根据维纳等人（1）的临床研究计算得出的。从该人群中排除Aa和aa个体后，分布显示为正态分布。“净”主要人群中的IgE几何平均值为33 U/ml。该值略高于近期关于IgE水平的研究值。不同年龄组的IgE平均水平与主要人群的平均水平相比没有显著差异，尽管随着年龄增长IgE水平有下降趋势是明显的。
