Barr B C, Conrad P A, Breitmeyer R, Sverlow K, Anderson M L, Reynolds J, Chauvet A E, Dubey J P, Ardans A A
California Veterinary Diagnostic Laboratory System, School of Veterinary Medicine, University of California, Davis 95616.
J Am Vet Med Assoc. 1993 Jan 1;202(1):113-7.
Four dairy cows that had been successfully rebred following fetal Neospora infection and abortion were identified from 2 drylot dairies. All 4 cows had uncomplicated pregnancies with the birth of 5 full-term calves. The calves all had high precolostral serum IgG antibodies. The precolostral antibodies to Neospora sp as determined by indirect fluorescent antibody test ranged from 5,120 to 20,480, compared with maternal serum and colostral antibody titers from 320 to 1,280. Two calves had mild neurologic limb deficits. Three calves had mild nonsuppurative encephalomyelitis and Neospora organisms were found in the CNS of 3 calves. Findings indicate that repeat transplacental Neospora infections occur in cows. Additionally, calves born from cows with a history of Neospora fetal infection and abortion may have congenital Neospora infections and/or neurologic dysfunctions at birth. The Neospora indirect fluorescent antibody test appears to be a useful antemortem test for detection of calves exposed in utero to Neospora organisms.
从两个干奶牛场中识别出4头在胎儿新孢子虫感染和流产后成功再次受孕的奶牛。这4头奶牛的怀孕过程均无并发症，共生下5头足月小牛。所有小牛的初乳前血清IgG抗体水平都很高。通过间接荧光抗体试验测定，小牛对新孢子虫属的初乳前抗体范围为5120至20480，而母体血清和初乳抗体滴度为320至1280。两头小牛有轻度神经肢体缺陷。三头小牛有轻度非化脓性脑脊髓炎，在三头小牛的中枢神经系统中发现了新孢子虫。研究结果表明，奶牛会发生反复经胎盘的新孢子虫感染。此外，有新孢子虫胎儿感染和流产史的母牛所生的小牛在出生时可能患有先天性新孢子虫感染和/或神经功能障碍。新孢子虫间接荧光抗体试验似乎是一种有用的生前检测方法，用于检测子宫内接触新孢子虫的小牛。
