Dreher R
Z Rheumatol. 1977 Jan-Feb;36(1-2):3-21.
Immunoglobulins were estimated quantitatively in sera from patients with rheumatoid arthritis. According to the significantly increased immunoglobulin class(es), in RA patients as compared to normals the following immunoglobulin patterns were registered: IgG pattern, IgM pattern, IgA pattern, IgG-IgM-IgA pattern, IgG-IgM pattern and IgG-IgA pattern. The IgG-, IgA- and IgG-IgM-IgA patterns were predominantly found in sera from patients with seropositive RA. A positive correlation was found between other inflammatory parameters and high titered rheumatoid factor of the IgG-IgM-IgA-, IgG-IgA- and IgM patterns. C-reactive proteins were increased more frequently in seropositive cases and correlated quantitatively with the IgG-IgA-, IgG-IgM-, IgG-IgM-IgA and IgA patterns. Maximal erythrocyte sedimentation rates were accompanied with the IgG-IgA-, IgG-IgM-IgA- and IgG-IgM pattern. The serum complement components C 3 and C 4 were not decreased in neither seropositive nor seronegative RA. The formation of antiglobulins in hypergammaglobulinemic patients with RA induced by an increased immunoglobulin catabolism is suggested as a possible pathogenetic mechanism.
对类风湿性关节炎患者的血清进行了免疫球蛋白定量检测。与正常人相比，类风湿性关节炎患者根据免疫球蛋白类别显著增加，呈现出以下免疫球蛋白模式：IgG模式、IgM模式、IgA模式、IgG-IgM-IgA模式、IgG-IgM模式和IgG-IgA模式。IgG、IgA和IgG-IgM-IgA模式主要见于血清阳性类风湿性关节炎患者。在其他炎症参数与IgG-IgM-IgA、IgG-IgA和IgM模式的高滴度类风湿因子之间发现了正相关。血清阳性病例中C反应蛋白升高更为频繁，且与IgG-IgA、IgG-IgM、IgG-IgM-IgA和IgA模式呈定量相关。最大红细胞沉降率与IgG-IgA、IgG-IgM-IgA和IgG-IgM模式相关。血清阳性和血清阴性类风湿性关节炎患者的血清补体成分C3和C4均未降低。免疫球蛋白分解代谢增加导致类风湿性关节炎高球蛋白血症患者抗球蛋白的形成被认为是一种可能的发病机制。
