类风湿关节炎和局部起源的反应性滑膜炎患者血清及滑液中的IgA1和IgA2亚类
Subclasses IgA1 and IgA2 in serum and synovial fluid in rheumatoid arthritis and reactive synovitis of local origin.
作者信息
Hrncír Z, Tichý M
出版信息
Ann Rheum Dis. 1978 Dec;37(6):518-21. doi: 10.1136/ard.37.6.518.
Subclasses IgA1 and IgA2 in serum were examined in 40 patients (28 cases of rheumatoid arthritis and 12 cases of reactive synovitis of local origin) and also in synovial fluid of the knee joint in 17 of these patients. The levels of IgA1 and IgA2 in serum were statistically significantly higher than in synovial fluid in both groups of patients (P = 0.0237--0.0018), but significant correlations between serum and synovial fluid for IgA1 (R = 0.8855, P = 0.0010) and for IgA2 (r = 0.7630, P = 0.0124) were found only in cases of rheumatoid arthritis. A percentage evaluation revealed a significant disproportion (P = 0.0028) in favour of IgA1 in synovial fluid during rheumatoid arthritis. The analysis of proportions of IgA subclasses and rheumatoid factor has shown no significant relationships.
对40例患者（28例类风湿性关节炎患者和12例局部反应性滑膜炎患者）的血清免疫球蛋白A1（IgA1）和免疫球蛋白A2（IgA2）亚类进行了检测，并对其中17例患者膝关节滑液中的这两种物质进行了检测。两组患者血清中IgA1和IgA2的水平均显著高于滑液中的水平（P = 0.0237 - 0.0018），但仅在类风湿性关节炎患者中发现血清与滑液中的IgA1（R = 0.8855，P = 0.0010）和IgA2（r = 0.7630，P = 0.0124）之间存在显著相关性。百分比评估显示，类风湿性关节炎期间滑液中IgA1占比显著失衡（P = 0.0028）。IgA亚类比例与类风湿因子的分析未显示出显著相关性。
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