Stojan B, Hasler F
Z Rheumatol. 1980 May-Jun;39(5-6):182-9.
In 31 case studies, 29 patients diagnosed with definite rheumatoid arthritis and 2 patients with probable rheumatoid arthritis were investigated. The duration of the disease averaged 8 years with 3 years being the minimum. These patients received either no basic therapy or had not been treated six months previous to the investigation. Patients with low levels of immunoglobulins were shown to have significantly better functional capacity (Steinbrocker) and significantly less synovitis, erosions and joint destructions despite longer duration of the disease than the control group with higher levels of immunoglobulins and C3-proactivator. All patients with this benign development of rheumatoid arthritis had an IgG-level below 1000 mg/100 ml (mean 767 mg/100 ml +/- 166) and low levels of IgA (mean 194 mg/100 ml +/- 73), IgM (mean 111 mg/100 ml +/- 53) and C3-proactivator (mean 23 mg/100 ml +/-6). 50% of these patients had positive rheumatoid factors.
在31个病例研究中，对29例确诊为类风湿性关节炎的患者和2例可能患有类风湿性关节炎的患者进行了调查。疾病持续时间平均为8年，最短为3年。这些患者要么未接受基本治疗，要么在调查前6个月未接受治疗。与免疫球蛋白和C3-前活化剂水平较高的对照组相比，免疫球蛋白水平较低的患者显示出明显更好的功能能力（斯坦布鲁克分级），滑膜炎、糜烂和关节破坏明显更少，尽管疾病持续时间更长。所有类风湿性关节炎呈良性发展的患者IgG水平低于1000mg/100ml（平均767mg/100ml±166），IgA（平均194mg/100ml±73）、IgM（平均111mg/100ml±53）和C3-前活化剂水平较低（平均23mg/100ml±6）。这些患者中有50%类风湿因子呈阳性。
