Hoe A L, Mullee M A, Royle G T, Guyer P B, Taylor I
Department of Radiology, Southampton.
Ann R Coll Surg Engl. 1993 Jan;75(1):18-22.
The influence of breast size on the prognosis of 196 patients with early breast cancer diagnosed in the period 1984-1985 was studied. Breast size was based on the volume from mammography. This method was validated against the volume of the mastectomy specimen determined by water displacement in 18 patients and found to be accurate (r = 0.93, P < 0.01). The median breast volume was 833.5 cm3 (interquartile range 522.8-1153.3 cm3). Breast size was significantly associated independently with age (Spearman's rank r = 0.24. P = 0.001), menstrual status (z = -4.81, P < 0.001), body weight (Spearman's rank r = 0.61, P < 0.001), T stage (z = -1.91, P = 0.05) but not N stage (z = -1.64, P = 0.10) or hormone receptor status (z = -0.80, P = 0.42). In an analysis of breast size and other known prognostic factors, based upon Cox's proportional hazards regression, N stage was the only significant factor for both breast cancer survival and disease-free survival. Even though women with larger tumours at presentation had larger breasts, breast size was not a significant prognostic factor in early breast cancer.
研究了1984年至1985年期间确诊的196例早期乳腺癌患者的乳房大小对预后的影响。乳房大小基于乳房X线摄影的体积。该方法通过对18例患者经水置换法测定的乳房切除标本体积进行验证，发现是准确的（r = 0.93，P < 0.01）。乳房体积中位数为833.5 cm³（四分位间距522.8 - 1153.3 cm³）。乳房大小与年龄（Spearman等级相关系数r = 0.24，P = 0.001）、月经状态（z = -4.81，P < 0.001）、体重（Spearman等级相关系数r = 0.61，P < 0.001）、T分期（z = -1.91，P = 0.05）显著独立相关，但与N分期（z = -1.64，P = 0.10）或激素受体状态（z = -0.80，P = 0.42）无关。在基于Cox比例风险回归对乳房大小和其他已知预后因素的分析中，N分期是乳腺癌生存和无病生存的唯一显著因素。尽管初诊时肿瘤较大的女性乳房也较大，但乳房大小并非早期乳腺癌的显著预后因素。
