转移性和非转移性神经系统疾病患者脑脊液中的神经元特异性烯醇化酶

Neuron-specific enolase in cerebrospinal fluid of patients with metastatic and non-metastatic neurological disease.

作者信息

Beelen N A, Twijnstra A, van de Pol M, Menheere P P

机构信息

Department of Neurology, University Hospital of Maastricht, The Netherlands.

出版信息

Eur J Cancer. 1993;29A(2):193-5. doi: 10.1016/0959-8049(93)90172-c.

DOI:10.1016/0959-8049(93)90172-c

PMID:8422282

Abstract

Neuron-specific enolase (NSE) activities were measured in cerebrospinal fluid (CSF) in 361 patients with various neurological diseases. CSF was collected as part of the diagnostic procedure both in the control group, which consisted of 189 subjects with low back pain, and in the patient group (172 patients). The mean CSF NSE level in 189 control subjects was 7.14 +/- 1.94 micrograms/l. Slight elevations of CSF NSE (> or = 11.0 micrograms/l) were observed in 9 patients with non-malignant diseases and in 2 patients with malignant diseases. The findings of this study indicate that measurement of NSE in CSF cannot be used as an adjunctive diagnostic test for CNS metastases.

摘要

在361例患有各种神经系统疾病的患者中测量了脑脊液（CSF）中的神经元特异性烯醇化酶（NSE）活性。作为诊断程序的一部分，收集了对照组和患者组的脑脊液，对照组由189例腰痛患者组成，患者组有172例患者。189例对照受试者的脑脊液NSE平均水平为7.14±1.94微克/升。在9例非恶性疾病患者和2例恶性疾病患者中观察到脑脊液NSE略有升高（≥11.0微克/升）。本研究结果表明，脑脊液中NSE的测量不能用作中枢神经系统转移的辅助诊断试验。