通过荧光原位杂交将人类胶原蛋白基因COL7A1定位于3p21.3。
Localization of the human collagen gene COL7A1 to 3p21.3 by fluorescence in situ hybridization.
作者信息
Greenspan D S, Byers M G, Eddy R L, Hoffman G G, Shows T B
机构信息
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53706.
出版信息
Cytogenet Cell Genet. 1993;62(1):35-6. doi: 10.1159/000133440.
An 8-kb genomic probe, containing 34 collagen-encoding exons, was localized to 3p21.3 by fluorescence in situ hybridization. The genomic probe encoded a previously uncharacterized carboxyl terminal portion of the alpha 1(VII) collagen chain. This mapping result confirms the previous assignment of the alpha 1(VII) gene (COL7A1) to 3p21 and offers a finer subregional localization than was previously available.
一个包含34个胶原蛋白编码外显子的8千碱基对基因组探针，通过荧光原位杂交定位到3p21.3。该基因组探针编码了α1（VII）胶原链先前未被表征的羧基末端部分。这一图谱绘制结果证实了先前将α1（VII）基因（COL7A1）定位于3p21的结果，并提供了比以前更精细的亚区域定位。
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