Fenig E, Lurie H, Sulkes A
Institute of Oncology, Beilinson Medical Center, Petah, Tiqva, Israel.
Am J Clin Oncol. 1993 Feb;16(1):54-7. doi: 10.1097/00000421-199302000-00014.
Five patients with advanced Merkel cell carcinoma (MCC) are described. Four patients with regional lymph node involvement and one with disseminated skin metastases were treated with systemic chemotherapy, including cyclophosphamide, methotrexate, and 5-fluorouracil (CMF). The patients received a median of six cycles of CMF (range: 2 to 6), and chemotherapy was well tolerated. Four complete and one partial response were noted. Three patients are alive and are disease-free at 5, 12, and 37 months from the onset of CMF chemotherapy. Two patients died from disseminated metastatic disease at 3 and 24 months from the onset of chemotherapy. CMF chemotherapy appears to be an active regimen in the treatment of locally advanced MCC. Further experience with this combination is warranted.
本文描述了5例晚期默克尔细胞癌（MCC）患者。4例有区域淋巴结受累和1例有播散性皮肤转移的患者接受了全身化疗，包括环磷酰胺、甲氨蝶呤和5-氟尿嘧啶（CMF）。患者接受CMF化疗的中位数为6个周期（范围：2至6个周期），化疗耐受性良好。观察到4例完全缓解和1例部分缓解。3例患者存活，自CMF化疗开始起5个月、12个月和37个月时无疾病。2例患者在化疗开始后3个月和24个月死于播散性转移性疾病。CMF化疗似乎是治疗局部晚期MCC的一种有效方案。有必要对这种联合方案进行进一步的研究。
