Hoffman W E, Thomas C, Albrecht R F
Department of Anestheiology, University of Illinois, Chicago.
Anesth Analg. 1993 Feb;76(2):279-83.
The relation between sympathetic activity and neurologic outcome was evaluated during fentanyl/nitrous oxide (N2O) (25 micrograms.kg-1.min-1 plus 70% N2O in oxygen), halothane (1.1% inspired), and isoflurane (1.4% anesthesia in a rat model of incomplete cerebral ischemia. Ischemia was produced by right carotid ligation combined with hemorrhagic hypotension to 30 mm Hg for 30 min. Plasma catecholamines were measured during ischemia. Neurologic outcome was measured for 3 days following incomplete ischemia. Both halothane and isoflurane decreased plasma catecholamines 50-80% and improved ischemic outcome compared to fentanyl/N2O anesthesia (P < 0.05). These results indicate a relation between the ability of inhaled anesthetics to decrease sympathetic activity and to improve outcome from incomplete cerebral ischemia.
在芬太尼/一氧化二氮（N₂O）（25微克·千克⁻¹·分钟⁻¹加70% N₂O于氧气中）、氟烷（吸入浓度1.1%）和异氟烷（麻醉浓度1.4%）麻醉下，在大鼠不完全性脑缺血模型中评估交感神经活动与神经学转归之间的关系。通过右侧颈动脉结扎联合出血性低血压至30 mmHg持续30分钟来制造缺血。在缺血期间测量血浆儿茶酚胺。在不完全性缺血后3天测量神经学转归。与芬太尼/N₂O麻醉相比，氟烷和异氟烷均使血浆儿茶酚胺降低50 - 80%，并改善了缺血转归（P < 0.05）。这些结果表明吸入麻醉药降低交感神经活动的能力与改善不完全性脑缺血转归之间存在关联。
