Ramanathan K B, Bodenheimer M M, Banka V S, Raina S, Helfant R H
Am J Cardiol. 1977 Mar;39(3):413-7. doi: 10.1016/s0002-9149(77)80098-2.
The comparative effects of dopamine and isoproterenol on local myocardial contraction and ischemic injury after coronary occlusion were evaluated in 10 dogs. Dopamine (2.5 to 5 mug/kg per min) and isoproterenol (0.125 to 0.25 mug/kg per min) were randomly infused for 20 minutes, and segmental tension (Walton-Brodie gauge) of central ischemic, border and nonischemic myocardial zones and epicardial electrograms (10 to 12 sites) were simultaneously recorded. After coronary occlusion, tension in border zones decreased to 73.5 +/- 6.4 percent (mean +/- standard error of the mean) and tension in central zones to 60.6 +/- 9.9 percent (P less than 0.001) of control level, whereas total S-T elevation (sigmaST) rose from 10.8 +/- 1.6 to 98.4 +/- 14.0 mv and average S-T elevation (ST) from 1.6 +/- 0.2 to 10.8 +/- 1.6 mv (P less than 0.001). Isoproterenol increased heart rate from 148.7 +/- 6.9 to 170.6 +/- 7.7 beats/min (P less than 0.010) and improved tension in the border zone to 110.5 +/- 8.5 percent (P less than 0.010) and improved tension in the border zone to 110.5 +/- 8.5 percent (P less than 0.005) and nonischemic zone to 128.4 +/- 6.7 percent (P less than 0.02). Tension in the central zone was unchanged. However, sigmaST increased from 98.4 +/- 14.0 to 126.9 +/- 14.7 mv (P less than 0.005) and ST from 10.8 +/- 1.6 to 14.2 +/- 1.6 mv (P less than 0.001). Dopamine did not change heart rate but increased tension in the border zone from 72.4 +/- 7.9 to 124.4 +/- 16.8 percent (P less than 0.001) and tension in the nonischemic zone from 86.0 +/- 10.0 to 133.3 +/- 10.0 percent (P less than 0.01). Tension in the central zone was unimproved. However, sigmaST and ST did not increase (sigmaST from 99.8 +/- 10.8 to 97.7 +/- 13.9 mv and ST from 11.1 +/- 1.3 to 10.8 +/- 1.5 mv). Atrial pacing was used to increase heart rate during infusion of dopamine to 180.0 +/- 7.6 beats/min but neither sigmaST nor ST increased. In summary, both dopamine and isoproterenol decrease contraction abnormalities in the border and nonischemic zones after after acute coronary occlusion. Although isoproterenol increases both heart rate and S-T segment elevation, dopamine does not adversely affect either variable.
在10只犬中评估了多巴胺和异丙肾上腺素对冠状动脉闭塞后局部心肌收缩及缺血性损伤的比较效应。多巴胺（2.5至5微克/千克每分钟）和异丙肾上腺素（0.125至0.25微克/千克每分钟）随机输注20分钟，同时记录中央缺血心肌区、边缘心肌区和非缺血心肌区的节段张力（Walton-Brodie测量仪）以及心外膜电图（10至12个部位）。冠状动脉闭塞后，边缘区张力降至对照水平的73.5±6.4%（平均值±平均值的标准误差），中央区张力降至60.6±9.9%（P<0.001），而总S-T段抬高（σST）从10.8±1.6毫伏升至98.4±14.0毫伏，平均S-T段抬高（ST）从1.6±0.2毫伏升至10.8±1.6毫伏（P<0.001）。异丙肾上腺素使心率从148.7±6.9次/分钟增至170.6±7.7次/分钟（P<0.010），边缘区张力改善至110.5±8.5%（P<0.010），非缺血区张力改善至128.4±6.7%（P<0.02）。中央区张力未改变。然而，σST从98.4±14.0毫伏增至126.9±14.7毫伏（P<0.005），ST从10.8±1.6毫伏增至14.2±1.6毫伏（P<0.001）。多巴胺未改变心率，但使边缘区张力从72.4±7.9%增至124.4±16.8%（P<0.001），非缺血区张力从86.0±10.0%增至133.3±10.0%（P<0.01）。中央区张力未改善。然而，σST和ST未增加（σST从99.8±10.8毫伏降至97.7±13.9毫伏，ST从11.1±1.3毫伏降至10.8±1.5毫伏）。在输注多巴胺期间使用心房起搏使心率增至180.0±7.6次/分钟，但σST和ST均未增加。总之，多巴胺和异丙肾上腺素均可减轻急性冠状动脉闭塞后边缘区和非缺血区的收缩异常。尽管异丙肾上腺素增加心率和S-T段抬高，但多巴胺对这两个变量均无不利影响。
